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Welcome to INO-ontology!

This website is devoted to the development of the Interaction Network Ontology (INO), Human Interaction Network Ontology (HINO), and other possible INO extensions.

The Interaction Network Ontology (INO) is a community-driven ontology that is developed to standardize and integrate data on interaction networks and support computer-assisted reasoning.

The Ontobee website for INO is here: http://www.ontobee.org/browser/index.php?o=INO

He group (Allen Xiang and Oliver He) has also developed an INO extension called Human Interaction Network Ontology (HINO).

The ontology information can be found from Ontobee: http://www.ontobee.org/browser/index.php?o=HINO

The HINO ontology has incorporated Reactome reactions and pathways associated with the human organism. Since INO aligns with BFO, HINO aligns with BFO as well.

The INO SPARQL can be used to query INO and HINO using the SPARQL technology.

The INO/HINO development has attracted many good international attenations and collaborations. If you have any comments and suggestions or would like to collaborate, please feel free to contact us.



Ozgur A, Xiang Z, Radev D, He Y. Mining of vaccine-associated IFN-γ gene interaction networks using the Vaccine Ontology. Journal of Biomedical Semantics. 2011, 2(Suppl 2):S8. PMID: 21624163. PMCID: PMC3102897. (Note: This is the first paper mentioning INO)

He Y, Xiang Z. HINO: BFO-aligned ontology representing human molecular interactions and pathways. Proceedings of the 2013 International Conference on Biomedical Ontologies (ICBO-2103), Montreal, Qc, Canada. July 8-9, 2013. URL: http://ceur-ws.org/Vol-1060/icbo2013_submission_70.pdf. (Note: This is the first presentation on HINO)

He Y, Xiang Z. HINO: a BFO-aligned ontology representing human molecular interactions and pathways. arXiv. 2013. arXiv:1311.3355. (Note: This is the full-length paper preprint detailing HINO)